Neonatal systemic candidiasis treated with miconazole.

Neonatal systemic candidiasis treated with miconazole.

Systemic neonatal candidiasis.

Forty-five cases of systemic neonatal candidiasis were diagnosed over a 9-year period in a neonatal intensive care unit; 42 infants weighted less than 1.5 kg. All had been very ill with preceding bacterial sepsis and other complications of low birthweight. Where treatment was instituted the mortality was low (4 out of 39 dying) and complications of treatment were transitory. We therefore recomm...

Neonatal systemic candidiasis.

Neonatal systemic candidiasis.

Ten babies who required neonatal intensive care developed systemic candidiasis. Eight were extremely preterm (28 weeks' gestation or less) and all received prolonged ventilation, multiple courses of broad spectrum antibiotics, and intravenous hyperalimentation. Diagnosis was established by culture of yeasts from suprapubic urine specimens; venous blood cultures proved unreliable. Initial treatm...

Neonatal systemic candidiasis: a failure to respond to intravenous miconazole in two neonates.

a superimposed nutritional deficiency which further impairs their resistance, especially to diarrhoeal disease. This suggests that one important cause of postneonatal mortality in Latin America is low birthweight, possibly as a result of poor maternal health and nutritional status. In other parts of the world-for example in Africa and the Indian subcontinent-the prevalence of low birthweight is...